Comparison of the Cardioprotective Effects of Nitroglycerin, Molsidomine, and SIN-1 in Rats

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Abstract
Summary: We tested the relative cardioprotective potencies and time course of the effects of nitroglycerin, molsidomine, and SIN-1 in the rat isoproterenol (ISO) model. ISO was injected at a dose of mg/kg intraperitoneally (i.p.) to rats daily for five consecutive days. We evaluated the developed hypoxia (HP) and necrosis (NC) quantitatively by histological methods. To follow the time course of cardioprotection, nitroglycerin, molsidomine, or SIN-1 were injected intraperitoneally daily at 60, 120, and 240 min before ISO to groups of ten rats, respectively. Cardioprotection was defined as the reduction in necrotized and hypoxic areas and was expressed as percentage change compared to the control (saline-treated) group. Nitroglycerin and molsidomine caused nearly equipotent cardioprotection, but the effect of molsidomine was more prolonged. Pretreatment with SIN-1 almost totally prevented the development of cardiac necrosis and hypoxia.

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