Pure red cell aplasia: further evidence of T cell clonal disorder
- 1 May 1994
- journal article
- case report
- Published by Wiley in British Journal of Haematology
- Vol. 87 (1) , 189-192
- https://doi.org/10.1111/j.1365-2141.1994.tb04890.x
Abstract
We report a patient with pure red cell aplasia and type I autoimmune polyglandular syndrome who also had an expansion of suppressor T lymphocytes in the peripheral blood. Southern blotting of DNA from these cells suggest T cell receptor (TCR) gamma gene rearrangement. We confirmed true clonality of this by amplification of the gene rearrangement using the polymerase chain reaction and subsequent analysis of the product by gene cloning and DNA sequencing.Keywords
This publication has 11 references indexed in Scilit:
- Clonal diseases of large granular lymphocytes [see comments]Blood, 1993
- Is pure red cell aplasia (PRCA) a clonal disorder?Clinical and Laboratory Haematology, 1993
- Granular lymphocyte leukemia with pure red cell aplasia: Usefulness of gene analysis in assessing therapeutic effectAmerican Journal of Hematology, 1992
- Detection of T-cell receptor gamma chain V gene rearrangements using the polymerase chain reaction: application to the study of clonal disease cells in acute lymphoblastic leukemiaBlood, 1991
- Human gamma delta T-cell receptor-positive cell-mediated inhibition of erythropoiesis in vitro in a patient with type I autoimmune polyglandular syndrome and pure red blood cell aplasia [see comments]Blood, 1990
- Heterogeneity of large granular lymphocyte proliferations: delineation of two major subtypesBlood, 1986
- T cell receptor gene rearrangements define a monoclonal T cell proliferation in patients with T cell lymphocytosis and cytopeniaBlood, 1986
- Two tandemly organized human genes encoding the T-cell γ constant-region sequences show multiple rearrangement in different T-cell typesNature, 1985
- Complexity of human T-cell antigen receptor β-chain constant- and variable-region genesNature, 1984
- Evidence for genetic restriction in the suppression of erythropoiesis by a unique subset of T lymphocytes in man.Journal of Clinical Investigation, 1983