DNA and RNA within the nucleus: How much sequence‐specific spatial organization?
- 1 October 1991
- journal article
- review article
- Published by Wiley in Journal of Cellular Biochemistry
- Vol. 47 (2) , 124-129
- https://doi.org/10.1002/jcb.240470205
Abstract
Spatial organization of various nuclear components is often proposed as means by which nuclei more efficiently carry out their various tasks. Such functional compartmentalization may involve a sequence‐specific packaging and placement of DNA and RNA. Here we review recent insights, allowed primarily by advances in fluorescent in situ hybridization methodology, into the organization of nucleic acids within individual nuclei.Keywords
This publication has 29 references indexed in Scilit:
- Preservation of specific RNA distribution within the chromatin-depleted nuclear substructure demonstrated by in situ hybridization coupled with biochemical fractionation.The Journal of cell biology, 1991
- Chromosome topology in mammalian interphase nucleiExperimental Cell Research, 1991
- Structure–function relationships in eukaryotic nucleiBioEssays, 1991
- A unified model of eukaryotic chromosomesCytometry, 1990
- Mammalian chromosome banding — an expression of genome organizationTrends in Genetics, 1989
- Mapping replicational sites in the eucaryotic cell nucleus.The Journal of cell biology, 1989
- Organization beyond the geneTrends in Biochemical Sciences, 1986
- Localization of DNAase I-sensitive sequences to specific regions of interphase nucleiCell, 1985
- Reversible chromosome condensation induced in Drosophila embryos by anoxia: visualization of interphase nuclear organization.The Journal of cell biology, 1985
- Correlation of hnRNP structure and nascent transcript cleavageCell, 1981