A facile stereoselective route to a C/D-ring synthon for 20-epi-22-oxavitamin D3 analogues

1 January 1995

journal article
research article
Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications

No. 19,p. 1959-1960
https://doi.org/10.1039/c39950001959

Abstract

An efficient method for the preparation of a C/D-ring synthon for 20-epi-22-oxavitamin D₃ analogues is developed based on Me₃SiOSO₂CF₃ catalysed reductive etherification of a ketone with an alkoxytrimethylsilane in the presence of triethylsilane.

Keywords

C/D
ETHERIFICATION
ME3SIOSO2CF3
KETONE
EFFICIENT
CATALYSED
ALKOXYTRIMETHYLSILANE
TRIETHYLSILANE
FACILE STEREOSELECTIVE

This publication has 0 references indexed in Scilit: