ACE Inhibitors for Patients with Vascular Disease without Left Ventricular Dysfunction — May They Rest in PEACE?

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Abstract
Angiotensin-converting–enzyme (ACE) inhibitors are effective in reducing mortality and morbidity from cardiovascular events among patients who have chronic heart failure due to left ventricular systolic dysfunction and in those who have acute myocardial infarction with or without left ventricular systolic dysfunction. ACE inhibitors are also effective in reducing mortality and morbidity from cardiovascular events in high-risk patients with diabetes mellitus as well as those with renal dysfunction. In addition, ACE inhibitors are effective antihypertensive agents, although current data suggest that they are not more effective in reducing mortality and morbidity from cardiovascular events than other classes of antihypertensive agents with . . .