Intestinal absorption of ursodeoxycholic, glycoursodeoxycholic and tauroursodeoxycholic acids in rats.
- 1 January 1985
- journal article
- research article
- Published by Pharmaceutical Society of Japan in Journal of Pharmacobio-Dynamics
- Vol. 8 (2) , 114-118
- https://doi.org/10.1248/bpb1978.8.114
Abstract
The intestinal absorption of ursodeoxycholic acid (UDC), glycoursodeoxycholic acid (GUDC) and tauroursodeoxycholic acid (TUDC) was examined in rats using an everted gut sac technique. UDC was absorbed throughout rat small intestine almost of the same extent. Absorption of both GUDC and TUDC varied between jejunum and ileum. Absorption of these conjugated bile acids in the jejunal segments was less than that of UDC. Absorption of GUDC and TUDC in the terminal ileum was more efficient than UDC. 2,4-Dinitrophenol had no effect on the jejunal uptake, ileal uptake of these 3 bile acids was inhibited by 2,4-dinitrophenol.This publication has 2 references indexed in Scilit:
- Cholesterol gallstone dissolution in bile: dissolution kinetics of crystalline (anhydrate and monohydrate) cholesterol with chenodeoxycholate, ursodeoxycholate, and their glycine and taurine conjugates.Journal of Lipid Research, 1981
- Effects of biliary bile acid composition on biliary cholesterol saturation in gallstone patients treated with chenodeoxycholic acid and/or ursodeoxycholic acidGastroenterology, 1980