CHANGES IN NEUROMUSCULAR BLOCKING ACTIVITY OF TUBOCURARINE AND DIMETHYL TUBOCURARINE INDUCED BY THE ADMINISTRATION OF CARBON DIOXIDE

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Abstract
SUMMARY: The effects of carbon dioxide on the neuromuscular blocking properties of dimethyl tubocurarine were studied in the intact cat and compared with the response of tubocurarine under similar circumstances.It was shown that the action of dimethyl tubocurarine was antagonised, whereas the action of tubocurarine was enhanced.Evidence was presented to indicate that the enhanced activity of tubocurarine was due to a change in the ionic state of the phenolic hydroxyl groups. No completely satisfactory explanation could be given for the reduced activity of dimethyl tubocurarine, but it was suggested that carbon dioxide modified the motor end‐plates in such a way that their resistance to relaxant drugs is increased.

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