Somatotropic Activity of U. S. Pharmacopeia Growth Hormone Reference Standard in Alkali or Acid.

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Abstract
U. S. Pharmacopeia Growth Hormone Reference Standard and a pork pituitary preparation obtained by the method of Raben were assayed for somatotropic activity by the 10-day growth test in hypophysectomized rats. U.S.P. Standard showed much greater potency in alkali than in acid, while the activity of the pork preparation in alkaline or acid media was the same. Using alkaline solutions the pork preparation was only one-third as active as the U.S.P. Standard, but when injections were made in an acid vehicle both preparations exhibited equi-potent activity. Since the U.S.P. Standard shows decreased activity when dissolved in acid, the use of an alkaline injection vehicle is recommended.
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