Humoral hypercalcaemia in a patient with renal-cell carcinoma

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Abstract
In a patient with hypercalcemia secondary to a renal-cell carcinoma, a concentration gradient of bioactivity was detected between the tumor effluent vein and the peripheral venous blood that was capable of stimulating adenylate cyclase in bone cells. Immunoreactive PTH was undetectable in the tumor effluent and in the peripheral blood. A nonparathyroid humoral factor whose action involved cyclic AMP stimulation was responsible for the hypercalcemia.