One-Pot Organocatalytic Direct Asymmetric Synthesis of γ-Amino Alcohol Derivatives

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Abstract
This report describes the unprecedented use of unmodified aldehydes as donors in catalytic three component one-pot asymmetric Mannich reactions. The Mannich-type reactions were also readily performed for the first time with both in situ generated and preformed N-PMP protected aromatic aldimines. The proline-catalyzed reactions provided an efficient and very mild entry to either enantiomer of γ-amino alcohol derivatives in high yield and stereoselectivity.

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