Phosphodiesterase type 5 inhibitors: a biochemical and clinical correlation survey
- 1 October 2003
- journal article
- review article
- Published by Springer Nature in International Journal Of Impotence Research
- Vol. 15 (S5) , S13-S19
- https://doi.org/10.1038/sj.ijir.3901067
Abstract
Phosphodiesterase type 5 (PDE 5) is the major cGMP hydrolyzing enzyme in penile corpus cavernosum and is an important regulator of nitric oxide-mediated smooth muscle relaxation. The critical role of PDE 5 in penile erection and the recent availability of specific and potent inhibitors of PDE 5 have enabled the development of effective oral treatment strategies that have been widely accepted by both health-care professionals and the lay public. This article examines the correlation between the available biochemical and clinical data for the PDE 5 inhibitors sildenafil (Viagra), tadalafil (Cialis) and vardenafil (Levitra).Keywords
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