EFFECT OF DIURESIS ON URINARY-EXCRETION AND CREATININE CLEARANCE IN THE HORSE

  • 1 January 1985
    • journal article
    • research article
    • Vol. 46  (8) , 1616-1618
Abstract
Endogenous creatinine clearance and renal excretion of phenylbutazone, osmotically active material, and compounds contributing to the urinary refractive index were studied in 12 Thoroughbred mares after no treatment, after water administration, or after furosemide administration. Urine was quantitatively collected, using urinary bladder catheters. On average, urine flow of the mares was 9 .mu.l/ml per kg without treatment and increased to about 50 .mu.l/min per kg after water administration and to about 70 .mu.l/min per kg after furosemide administration. Water administration increased creatinine clearance values and excretion of phenylbutazone. Furosemide administration increased urinary excretion of osmotically active compounds and compounds contributing to urinary refractive index and decreased excretion of phenylbutazone.