beta-endorphin is a potent analgesic agent.
- 1 August 1976
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 73 (8) , 2895-2898
- https://doi.org/10.1073/pnas.73.8.2895
Abstract
.beta.-Endorphin, an opiate-like peptide, has potent antinociceptive properties when it is administered directly into the brain and assayed in the tail-flick, hot-plate and writhing tests in mice and in the wet shake test in rats. On a molar basis, .beta.-endorphin is 18-33 times more potent than morphine, and its actions are blocked by the specific opiate antagonist, naloxone hydrochloride. The activity of .beta.-endorphin in vivo is also compared to other peptides that show opiate-like activity in assays in vitro.This publication has 22 references indexed in Scilit:
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