An Oral Mycobacterium bovis BCG Vaccine for Wildlife Produced in the Absence of Animal-Derived Reagents
- 1 September 2009
- journal article
- Published by American Society for Microbiology in Clinical and Vaccine Immunology
- Vol. 16 (9) , 1378-1380
- https://doi.org/10.1128/cvi.00198-09
Abstract
Cultures of Mycobacterium bovis BCG, comprising predominantly single-cell bacilli, were prepared in broth without animal-derived reagents. When formulated into a vegetable-derived lipid matrix, the vaccine was stable in vitro and was immunogenic in vivo upon feeding it to mice. This formulation could be useful for oral vaccination of wildlife against tuberculosis, where concern over transmissible prions may preclude the field use of vaccines containing animal products.Keywords
This publication has 11 references indexed in Scilit:
- LIPID-FORMULATED BCG AS AN ORAL-BAIT VACCINE FOR TUBERCULOSIS: VACCINE STABILITY, EFFICACY, AND PALATABILITY TO BRUSHTAIL POSSUMS (TRICHOSURUS VULPECULA) IN NEW ZEALANDJournal of Wildlife Diseases, 2009
- Oral vaccination reduces the incidence of tuberculosis in free-living brushtail possumsProceedings Of The Royal Society B-Biological Sciences, 2009
- Protection of free-living and captive possums against pulmonary challenge with Mycobacterium bovis following oral BCG vaccinationTuberculosis, 2009
- Oral vaccination against bovine tuberculosis withMycobacterium bovisBCGExpert Review of Vaccines, 2007
- Oral vaccination of mice with lipid-encapsulated Mycobacterium bovis BCG: Effect of reducing or eliminating BCG load on cell-mediated immunityVaccine, 2007
- Oral vaccination of wildlife against rabies: opportunities and challenges in prevention and control.2004
- Oral vaccination with Mycobacterium bovis BCG in a lipid formulation induces resistance to pulmonary tuberculosis in brushtail possumsVaccine, 2003
- Oral Delivery ofMycobacterium bovisBCG in a Lipid Formulation Induces Resistance to Pulmonary Tuberculosis in MiceInfection and Immunity, 2003
- Cultivation of Mycobacterium bovis BCG in bioreactorsJournal of Biotechnology, 2002
- Size effect on systemic and mucosal immune responses induced by oral administration of biodegradable microspheresVaccine, 1996