Propylthiouracil, a selective inhibitor of NADH‐cytochrome b5 reductase
- 1 December 1986
- journal article
- Published by Wiley in FEBS Letters
- Vol. 209 (1) , 49-51
- https://doi.org/10.1016/0014-5793(86)81082-1
Abstract
Propylthiouracil inhibited the activity of NADH-cytochrome b 5 reductase of rat liver microsomes using potassium ferricyanide as electron acceptor. On the other hand, NADPH-cytochrome P-450 reductase activity was not affected by the compound. NADH-supported reduction of cytochrome b 5 was also inhibited by Propylthiouracil in the reconstituted system consisting of cytochrome b 5 and partially purified NADH-cytochrome b 5 reductase.Keywords
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