Host factors and the pathogenesis of HIV-induced disease
Open Access
- 1 December 1996
- journal article
- review article
- Published by Springer Nature in Nature
- Vol. 384 (6609) , 529-534
- https://doi.org/10.1038/384529a0
Abstract
The level of human immunodeficiency virus (HIV) replication in patients reflects a balance between stimulatory and inhibitory host factors (particularly endogenous cytokines). New information concerning the cellular co-receptors for HIV and the cellular tropism of different strains of virus will advance our understanding of HIV-induced pathogenesis and suggests new therapeutic and preventive strategies.Keywords
This publication has 116 references indexed in Scilit:
- CD4-dependent, antibody-sensitive interactions between HIV-1 and its co-receptor CCR-5Nature, 1996
- Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1Nature, 1996
- Controlling HIV pathogenesis: the role of the noncytotoxic anti-HIV response of CD8+ T cellsImmunology Today, 1996
- HIV-1 Dynamics in Vivo: Virion Clearance Rate, Infected Cell Life-Span, and Viral Generation TimeScience, 1996
- Immune activation is a dominant factor in the pathogenesis of African AIDSImmunology Today, 1995
- Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infectionNature, 1995
- Viral dynamics in human immunodeficiency virus type 1 infectionNature, 1995
- A TH1→TH2 switch is a critical step in the etiology of HIV infectionImmunology Today, 1993
- Cell-Mediated Immune Response to Human Immunodeficiency Virus (HIV) Type 1 in Seronegative Homosexual Men with Recent Sexual Exposure to HIV-1The Journal of Infectious Diseases, 1992
- WHO WILL GET AIDS?The Lancet, 1986