ACUTE AND CHRONIC EFFECTS OF THE INSECTICIDE ENDRIN ON RENAL FUNCTION AND RENAL HEMODYNAMICS

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Abstract
Variable effects of chlorinated hydrocarbon insecticides on the kidney have been reported. The purpose of the present study was to determine the acute and chronic effects of the insecticide endrin on renal function and hemodynamics in dogs. Dogs were exposed to endrin acutely by intravenous infusion, and chronically by intramuscular injection. In acute experiments, dogs developed systemic hypertension and increased renal vascular resistance attributable to a sympatho-adrenal action. Acute effects of endrin were predominantly afferent arteriolar vasoconstriction as evidenced by decreases in renal blood flow, glomerular filtration rate, and urine flow. Phentolamine and phenoxybenzamine increased renal blood flow after endrin, providing evidence for humorally induced renal vasoconstriction due to adrenergic agents. Adrenalectomy partially offset the marked drop in renal blood flow after endrin although systemic hypertension and bradycardia were unaffected. Results from renal denervation experiments were variable. Changes in renal function in chronic studies were minimal and appeared to be due to secondary alterations in systemic hemodynamics. Results from this investigation provide no evidence for renal failure attributable to the direct effects of endrin.