Characterization of IgG complexes in eluates from rheumatoid tissue.

  • 1 February 1971
    • journal article
    • Vol. 8  (2) , 249-62
Abstract
Eluates of rheumatoid synovial and other rheumatoid granulation tissues both from seropositive and seronegative patients contained complexes of IgG, reacting with isolated IgM rheumatoid factor. According to gel filtration patterns, the molecular size of the complexes was similar to or even higher than that of heat-aggregated IgG. Patients with active disease and large amounts of IgG complexes in the tissue eluates often had low titres of free IgM rheumatoid factor both in eluates and in serum. This suggested an in vivo binding of IgM rheumatoid factor to tissue IgG complexes.