prICE: a downstream target for ceramide-induced apoptosis and for the inhibitory action of Bcl-2
- 15 May 1996
- journal article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 316 (1) , 25-28
- https://doi.org/10.1042/bj3160025
Abstract
The novel lipid second messenger, ceramide, specifically induced poly(ADP-ribose) polymerase cleavage through activation of the protease prICE. Over-expression of Bcl-2 inhibited ceramide-induced poly(ADP-ribose) polymerase proteolysis and protected cells from ceramide-induced death. These data provide the first insight into the mechanism by which ceramide mediates apoptosis and suggest a mechanism by which Bcl-2 protects from cell death.Keywords
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