Rate-independent test of reinforcing consequences of brain stimulation.

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Abstract
Rats were tested for reinforcing consequences of brain stimulation in a 2-platform chamber. The platform which provided stimulation was randomly switched and percentage of time on positive side was recorded. Experiments justified the conclusions (a) At a range of intensities, time measure and self-stimulation rate yielded parallel results; the former is more amenable to statistical evaluation. (b) Platform procedure resulted in reliably reflected change in stimulus parameters and condition of tissue surrounding electrode. (c) Threshold information with aversive or positive placements was obtainable. (d) Newly implanted naive Ss were conveniently "screened." (e) E could manipulate variables which S controlled in self-stimulation methods. (f) Time measures minimized influence of activity level and performance capability on estimate of reinforcement value.