Red-Cell Sodium-Potassium Pump in Obesity

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To the Editor: A lower ouabain binding at one hour in obese subjects, as shown in Figure 1 of the article by De Luise et al. in the October 30 issue, may be a consequence of slower ouabain binding (decreased affinity) rather than of fewer pump sites. It has been shown that ouabain binding is stable and that the dissociation rate is very slow.1 Thus, values for ouabain binding measured at submaximal concentrations of ouabain at one hour are not steady-state values, since higher values may be obtained with longer incubation. Therefore, it is possible to interpret the data in Figure 1 to indicate . . .