EG2 expressed by eosinophils as a clinically useful indicator of asthma

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Abstract
The monitoring of airway inflammation is mandatory for the improved control of bronchial asthma. We previously reported that intracellular EG2 levels of eosinophils, a marker of bronchial asthma increased in asthma patients. In this study, we hypothesized that eosinophil EG2+ expression increases during airway inflammation in asthmatic individuals. Eosinophil EG2+ and percentage eosinophil EG2+ with whole blood flow cytometry, eosinophil counts, serum total IgE, serum eosinophil cationic protein, eosinophil-derived neurotoxin, and percent of forced expiratory volume in 1 second/force vital capacity (FEV1/FVC) were measured in 33 asthmatic patients and 22 healthy volunteers. The relationships between these markers were evaluated. Comparisons were made on EG2+ expression between attack and asymptomatic periods in six asthmatic patients. EG2+ expression was significantly greater in the asthmatic patients than in healthy subjects. Furthermore, the EG2+ expression showed a significant increase during attacks. EG2+ expression inversely correlated with the FEV1/FVC. These results suggest that EG2+ expression may be a useful clinical marker of airway inflammation in asthma.

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