Cellular Level of Purine Compounds in Ischemic Gerbil Brain by High Performance Liquid Chromatography
- 1 March 1982
- journal article
- Published by Wiley in Journal of Neurochemistry
- Vol. 38 (3) , 833-835
- https://doi.org/10.1111/j.1471-4159.1982.tb08706.x
Abstract
The cellular level of ATP and related compounds in ischemic gerbil brain was investigated by high performance liquid chromatography (HPLC). Brain samples were obtained in situ following ligation of the common carotid artery. AMP and ADP peaks in the brain extracts in the ischemic group became much larger whereas the ATP peak decreased dramatically. The most striking finding was an extensive increase of adenosine: 50–100 fold. The levels of inosine and hypoxanthine also increased greatly in typical symptomatic gerbil.Keywords
This publication has 6 references indexed in Scilit:
- The Metabolism of Purine and Pyrimidine Nucleotides in Rat Cortex During Insulin‐Induced Hypoglycemia and RecoveryJournal of Neurochemistry, 1981
- POST‐ISCHEMIC CHANGES IN CERTAIN METABOLITES FOLLOWING PROLONGED ISCHEMIA IN THE GERBIL CEREBRAL CORTEXJournal of Neurochemistry, 1976
- Release of Adenosine from Ischemic BrainCirculation Research, 1974
- PURINE NUCLEOTIDE METABOLISM IN THE CAT BRAIN AFTER ONE HOUR OF COMPLETE ISCHEMIAJournal of Neurochemistry, 1974
- Cerebral ATP and Lactate Levels in the Squirrel Monkey Following Occlusion of the Middle Cerebral ArteryStroke, 1971