Some observations on the behaviour of hypothalamic enzymes during the time of blastocyst implantation in the rabbit

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Abstract
Hypothalami from pregnant and non-pregnant rabbits were homogenized in sucrose and separated into fractions by differential and density-gradient centrifugation. The fractions were examined for enzymes capable of inactivating oxytocin. Enzyme activity was detected in the supernatant and one participate fraction of both pregnant and non-pregnant animals. The specific activity of the enzymes increased during early pregnancy, and coincided with the time of blastocyst spacing and implantation in the uterus.