MYOCARDIAL DAMAGE AFTER REPETITIVE DIRECT-CURRENT SHOCK IN DOG - CORRELATION BETWEEN LEFT-VENTRICULAR END-DIASTOLIC PRESSURE AND EXTENT OF MYOCARDIAL NECROSIS

  • 1 January 1978
    • journal article
    • research article
    • Vol. 91  (2) , 272-279
Abstract
Acute myocardial necrosis was produced in 27 anesthetized dogs by repetitive DC 75 J shock delivered with 1 electrode in the left ventricular cavity and the other on the left chest wall. A total of 1 shock/kg body weight delivered at 10 s intervals resulted in discrete anterior wall necrosis of 7% to 31% (mean, 17.6%) of the mass of left ventricular myocardium. After some transient bradycardia, normal sinus rhythm was restored. Depression of left ventricular function 15 min after shock (rise in LVEDP [left ventricular end-diastolic pressure] from 4.0 .+-. 1.5 to 17 .+-. 2 mm Hg and fall in cardiac output from 2.29 .+-. 0.24 to 1.82 .+-. 0.12 l/min) recovered only slightly during the ensuing 2 h. A significant correlation (r = 0.85) was observed between the LVEDP at 2 h after shock and the extent of necrosis determined histochemically and histologically at the time of sacrifice 3 h after shock. Thus, in this form of acute myocardial damage, pump dysfunction is closely related to the area of necrosis.

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