Genetic analysis of renal function in mice. 1. Glomerular filtration rate and its correlation with body and kidney weight
Open Access
- 1 July 1981
- journal article
- research article
- Published by SAGE Publications in Laboratory Animals
- Vol. 15 (3) , 267-272
- https://doi.org/10.1258/002367781780893731
Abstract
Investigation of 18 inbred and 6 F1 hybrid mouse strains has shown that the glomerular filtration rate, bodyweight and kidney weight showed strain- and sex-dependent differences. Covariance analysis showed stronger correlations (genetic and environmental) between glomerular filtration rate and bodyweight than between glomerular filtration rate and kidney weight. This was predominantly due to a high within-strain variation of kidney weight (56%) in male mice. Therefore an allometric regression was calculated between the 48 strain means of glomerular filtration rate (GFR) and bodyweight (BW): GFR = 0·036 × BW0·74 Thus the term BW0·74 a suitable correction term for comparing the heat production of different species, is also suitable for the correction of glomerular filtration rate within one species.This publication has 2 references indexed in Scilit: