EFFECTS OF ACETYLCHOLINE, NOREPINEPHRINE AND SEROTONIN UPON THE SPONTANEOUS ACTIVITY OF SEPTAL UNITS INVITRO

  • 1 January 1982
    • journal article
    • research article
    • Vol. 32  (2) , 319-326
Abstract
Effects of Ach [acetylcholine], NE [norepinephrine] and 5HT [5-hydroxytryptamine], introduced into the bath medium, were investigated in 75 units recorded extracellularly in slices of guinea pig septum. Equally high reactivity to all 3 substances was observed (86-88% of reactive units). Ach evoked slowly developing moderate increase of spontaneous activity in 63% of the units; in 24% it enhanced, accelerated, or evoked rhythmic bursts (1-3.5/s). NE evoked higher and rapidly developing activation in 73% of the units; 5HT increased or decreased the level of activity in equal proportions of the cells (45% each). Both NE and 5HT neither provoked nor intensified rhythmic burst activity. Activatory and inhibitory effects of NE, 5HT and Ach were not blocked in the medium with high Mg2+ concentration. Burst activity disappeared in this condition in some units, but was preserved in the others. In some of the septal units transmitter substances modulate the activity of endogenous pacemaker mechanism.

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