COMPARATIVE STUDIES ON ANTITUMOR ACTIVITY AND BONE-MARROW TOXICITY OF 1-(BETA-D-GLUCOPYRANOSYL)-3-(2-CHLOROETHYL)-3-NITROSOUREA AND 2-[3-(2-CHLOROETHYL)-3-NITROSOUREIDO]-D-GLUCOPYRANOSE

  • 1 January 1977
    • journal article
    • research article
    • Vol. 68  (2) , 247-250
Abstract
Antitumor activity and bone marrow toxicity of a new nitrosourea analog, 1-(.beta.-D-glucopyranosyl)-3-(2-chloroethyl)-3-nitrosourea (GANU), were compared with those of 2-[3-(2-chloroethyl)-3-nitrosoureido]-D-glucopyranose (chlorozotocin) and 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU). GANU was highly active against mouse leukemia L-1210 when administered i.p. or i.v. to the same degree as chlorozotocin. Even by the oral route, GANU exhibited significant activities, whereas chlorozotocin failed to show any activity by this route. Studies on bone marrow toxicity as measured by the depression of white blood cell counts and marrow cellularity revealed that GANU and chlorozotocin were less toxic than BCNU. GANU seemed to be more toxic than chlorozotocin.

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