In vitro and in vivo genotoxicity of 1,3-butadiene and metabolites.
- 1 June 1990
- journal article
- review article
- Published by Environmental Health Perspectives in Environmental Health Perspectives
- Vol. 86, 75-78
- https://doi.org/10.1289/ehp.908675
Abstract
1,3-Butadiene and two major genotoxic metabolites 3,4-epoxybutene (EB) and 1,2:3,4-diepoxybutane (DEB) were used as model compounds to determine if genetic toxicity findings in animal and human cells can aid in extrapolating animal toxicity data to man. ...Keywords
This publication has 28 references indexed in Scilit:
- Comparative cytogenetic analysis of bone marrow damage induced in male B6C3F1 mice by multiple exposures to gaseous 1,3‐butadieneEnvironmental Mutagenesis, 1987
- Macrocytic-megaloblastic anemia in male B6C3F1 mice following chronic exposure to 1,3-butadieneToxicology and Applied Pharmacology, 1986
- Sister chromatid exchange and chromosome aberration analyses in mice after in vivo exposure to acrylonitrile, styrene, or butadiene monoxideEnvironmental Mutagenesis, 1986
- The reaction of 3, 4-epoxy-1-butene with deoxyguanosine and DNA in vitro: synthesis and characterization of the main adductsCarcinogenesis: Integrative Cancer Research, 1984
- Induction and rapid repair of sister-chromatid exchanges in multiple murine tissues in vivo by diepoxybutaneMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1983
- The mutagenicity of butadiene towards salmonella typhimuriumToxicology Letters, 1980
- Mutagenicity of butadiene and butadiene monoxideBiochemical and Biophysical Research Communications, 1978
- The mutagenic activity of diepoxybutane in yeastMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1975
- Methods for detecting carcinogens and mutagens with the salmonella/mammalian-microsome mutagenicity testMutation Research/Environmental Mutagenesis and Related Subjects, 1975
- Interstrand cross-linking of DNA by difunctional alkylating agentsJournal of Molecular Biology, 1967