Mutations in a Nonessential Viral Gene Permit Bacteriophage T4 to Form Plaques on Escherichia coli valS ts relA
- 11 July 1980
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 209 (4453) , 294-295
- https://doi.org/10.1126/science.6992274
Abstract
During viral development bacteriophage T4 modifies the valyl-transfer RNA synthetase of its host Escherichia coli, but the function of the modification has remained elusive. A strain of Escherichia coli has now been identified which is nonpermissive for wild-type bacteriophage T4, but permissive for bacteriophage mutants impaired in the modification reaction. A comparison with other bacteria suggests that nonpermissiveness is due to synthesis of a thermolabile valyl-transfer RNA synthetase and relaxed control of RNA accumulation.Keywords
This publication has 11 references indexed in Scilit:
- General screening procedure for RNA modificationless mutants: isolation of Escherichia coli strains with specific defects in RNA methylationJournal of Bacteriology, 1978
- The genome of bacteriophage T4Microbiology and Molecular Biology Reviews, 1976
- Effect of T4 modification of host valyl-tRNA synthetase on enzyme action in vivoVirology, 1975
- A gene of bacteriophage T4 controlling the modification of host valyl-tRNA synthetaseVirology, 1975
- REGULATION OF BACTERIAL ppGpp AND pppGppAnnual Review of Microbiology, 1975
- Viral Modification of the Valyl Transfer Ribonucleic Acid Synthetase of Escherichia coliJournal of Biological Chemistry, 1972
- Phage-Induced modification of valyl-tRNA synthetaseJournal of Cellular Physiology, 1969
- Amino Acid Regulation of Messenger Ribonucleic Acid Synthesis in T4-infected Escherichia coliJournal of Bacteriology, 1969
- Phage-induced Appearance of a Valyl sRNA Synthetase Activity in Escherichia coliCold Spring Harbor Symposia on Quantitative Biology, 1966
- Protein and Nucleic Acid Synthesis in Two Mutants of Escherichia coli with Temperature-Sensitive Aminoacyl Ribonucleic Acid SynthetasesJournal of Bacteriology, 1965