2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) promotes the transformation of C3H/10T1/2 cells

1 January 1985

journal article
Published by Oxford University Press (OUP) in Carcinogenesis: Integrative Cancer Research

Vol. 6 (4) , 651-653
https://doi.org/10.1093/carcin/6.4.651

Abstract

Continuous treatment of C3H/10T1/2 cells with low concentrations (>4pM) of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) enhanced focus production in cultures pretreated with N-methyl-N'-nitro-N-nitrosoguanidine. Maximal enhancement occurred at 40 pM TCDD, a concentration 10 000-fold lower than that required to produce an optimal response with 12-O-tetradecanoylphorboI-13-acetate. Single treatments with 0.06 nM-5 µM TCDD did not transform C3H/10T1/2 cells or initiate the process of transformation in cultures subsequently exposed to the tumor promoter 12-Otetradecanoylphorbol-13-acetate. Promotion of transformation is thus the predominant effect of TCDD in the C3H/101/2 cell transformation system.

Keywords

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