S cases have increased levels of interleukin‐6 in cerebrospinal fluid
- 1 February 1995
- journal article
- Published by Wiley in Acta Paediatrica
- Vol. 84 (2) , 193-196
- https://doi.org/10.1111/j.1651-2227.1995.tb13608.x
Abstract
Cerebrospinal fluid (CSF) from 20 infants who died of sudden infant death syndrome (SIDS), 7 cases of infectious death and 5 cases of violent death were examined with respect to concentrations of interleukin-6 (IL-6). The measurements were performed by ELISA. IL-6 levels in SIDS were significantly lower than in infectious death (p < 0.02), but significantly higher than in violent death (p < 0.02). Since IL-6 plays an important role in immune responses and may induce fever, the findings may suggest that immune activation plays a role in SIDS. The presence of cytokines in the central nervous system (CNS) may cause respiratory depression, especially in vulnerable infants.Keywords
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