Pertussis Vaccine
- 1 March 2009
- journal article
- research article
- Published by Wolters Kluwer Health in The Pediatric Infectious Disease Journal
- Vol. 28 (3) , 237-241
- https://doi.org/10.1097/inf.0b013e31818a8958
Abstract
A critical level of serum IgG pertussis toxin antibody is both essential and sufficient to confer individual and herd immunity to pertussis. Monocomponent pertussis toxoid conferred such immunity in Sweden and in Denmark. We refute the notion that filamentous hemagglutinin, pertactin, and fimbriae add to the immunity conferred by pertussis toxoid and describe the artifact created when efficacy is estimated for multicomponent pertussis vaccines. Lastly, the genetically-inactivated mutant pertussis toxoid is safer, more immunogenic, and should be more effective than the current chemically-inactivated pertussis toxin.Keywords
This publication has 70 references indexed in Scilit:
- Pertussis Toxin Targets Airway Macrophages To PromoteBordetella pertussisInfection of the Respiratory TractInfection and Immunity, 2007
- Characterization of Serological Responses to PertussisClinical and Vaccine Immunology, 2006
- Establishment of Diagnostic Cutoff Points for Levels of Serum Antibodies to Pertussis Toxin, Filamentous Hemagglutinin, and Fimbriae in Adolescents and Adults in the United StatesClinical and Vaccine Immunology, 2004
- Acellular pertussis vaccine given by accelerated schedule: response of preterm infantsArchives of Disease in Childhood: Fetal & Neonatal, 2004
- Antibody Responses to Bordetella pertussis Antigens and Clinical Correlations in Elderly Community ResidentsClinical Infectious Diseases, 2000
- Correlation between Pertussis Toxin IgG Antibodies in Postvaccination Sera and Subsequent Protection against PertussisThe Journal of Infectious Diseases, 2000
- Randomised controlled trial of two-component, three-component, and five-component acellular pertussis vaccines compared with whole-cell pertussis vaccineThe Lancet, 1997
- Unchanged efficacy of a pertussis toxoid vaccine throughout the two years after the third vaccination of infantsThe Pediatric Infectious Disease Journal, 1997
- History of whooping cough in nonvaccinated Swedish children, related to serum antibodies to pertussis toxin and filamentous hemagglutininThe Journal of Pediatrics, 1990
- Parapertussis: Clinical and serologic observationsThe Journal of Pediatrics, 1941