VASCULAR TYPE I ALDOSTERONE BINDING SITES ARE PHYSIOLOGICAL MINERALOCORTICOID RECEPTORS
- 1 October 1989
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 125 (4) , 2224-2226
- https://doi.org/10.1210/endo-125-4-2224
Abstract
In vitro, Type I receptors have high and equivalent affinity for aldosterone, corticosterone and cortisol:in vivo, physiological mineralocorticoid target tissues (kidney, colon, parotid) are highly aldosterone-selective, in contrast with hippocampus and heart. In the present study we show that the mesenteric vascular arcade is similarly highly aldosterone-selective in vivo, and in vitro shows considerable levels of 11.beta. OH steroid dehydrogenase activity, previously postulated as the mechanism whereby glucocorticoids are excluded from physiological mineralocorticoid receptors.This publication has 10 references indexed in Scilit:
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