Measles-Mumps-Rubella Immunization of Susceptible Hospital Employees During a Community Measles Outbreak Cost-Effectiveness and Protective Efficacy

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Abstract
Objective: To determine cost-effectiveness and protective efficacy of a program to identify and immunize susceptible hospital employees during a measles outbreak.Design: A cost analysis was made of blind measles-mumps-rubella (MMR) immunization versus directed MMR immunization based on 2,000 employees born after December 31, 1956. A directed MMR immunization program for susceptible employees was instituted. Actual costs of the program were calculated at the conclusion of the program.Setting: A medical center complex with more than 4,000 employees, two acute care community hospitals, and a tertiary care children's hospital.Results: A directed MMR immunization program was projected to he less expensive than blind immunization ($23,106 versus $70,720). MMR vaccine was administered to 169 of 188 susceptible employees. Actual cost of the directed MMR immunization program was $25,384.Conclusions: The directed MMR immunization program was cost-effective and prevented secondary cases among hospital employees during a community measles outbreak.