Changes in the amounts of linoleic acid in the serum of patients with multiple sclerosis

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Abstract
The levels of the 8 most abundant fatty acids present in the blood serum were determined chromatographically in samples from 26 patients with multiple sclerosis and 20 controls. Means values for myristic, palmitic, palmitoleic and oleic acids were significantly lower in healthy women than in the men. Values for linoleic and other acids were essentially the same for both sexes. In 5 female neurological controls the values for palmitoleic and oleic acids were significantly higher than those of healthy female controls. Serum levels of stearic, linoleic, eicosatrienoic and arachidonic acids were essentially the same for the healthy and for the neurological controls regardless of sex. Linoleic acid was the only fatty acid which demonstrated significant differences between the patients with multiple sclerosis and the controls. Serum linoleate levels decreased significantly in patients showing evidence of recent deterioration whereas the levels were within the normal range during the inactive phases of the disease.

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