Aortic endothelial cell replication. I. Effects of age and hypertension in the rat.
- 1 August 1977
- journal article
- research article
- Published by Wolters Kluwer Health in Circulation Research
- Vol. 41 (2) , 248-255
- https://doi.org/10.1161/01.res.41.2.248
Abstract
The daily rate of cell replication in the aortic endothelium of the normal rat falls from a maximum of 13% at birth to 0.1-0.3% at age 5-6 months. This residual rate of replication largely represents the turnover rate of the endothelium in normal animals. After renal hypertension of 2-3 weeks duration, however, the rate of replication rises 10-fold to an average value of 1.6%. This increase may represent an increase in turnover; however, it probably represent, at least in part, a proliferative response to cover the expanded luminal surface of the dilated vessel.This publication has 9 references indexed in Scilit:
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