False Increases of Troponin I Attributable to Incomplete Separation of Serum
Open Access
- 1 May 1999
- journal article
- Published by Oxford University Press (OUP) in Clinical Chemistry
- Vol. 45 (5) , 714
- https://doi.org/10.1093/clinchem/45.5.714
Abstract
In the process of establishing a troponin I assay in our laboratory, we found limited data on reference intervals for plasma. Because our laboratory relies heavily on plasma rather than serum to expedite analysis (1), we undertook a parallel study of serum and plasma troponin I concentrations with the Abbott AxSYMTM assay. To our surprise, we found several discordant results (Table 1). Reanalysis of the samples reproduced the discrepant results. However, when one of the serum samples was recentrifuged, reanalysis produced results essentially the same as those obtained from the matching plasma sample. After the other discordant serum samples were recentrifuged and reanalyzed, all serum and plasma results were similar. Additional samples, purposely allowed to contain tiny fibrinstrands, also produced increased troponin I results.Keywords
This publication has 1 reference indexed in Scilit:
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