Mucosal dosage form of lidocaine for toothache using hydroxypropyl cellulose and Carbopol.

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Abstract
Using hydroxypropyl cellulose-H (HPC) and Carbopol-934 (CP), a dosage form containing a local anesthetic for toothache was developed using lidocaine as a model drug in HPC and CP as the peripheral base. The dissolution profile of lidocaine was investigated with various mixing ratios of freeze-dried HPC/CP (FD-HPC/CP) to lidocaine in the core base, and the absorption when this dosage form was applied to the humans gingiva was studied. The dissolution rate was delayed with increase in the amount of FD-HPC/CP in the core base and the absorption of lidocaine was .apprx. 30% after 1 h and then increased by .apprx. 10% of the initial amount per h for 4 h in preparations containing 5 and 10 mg o FD-HPC/CP.

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