Host resistance to a fungal tomato pathogen lost by a single base-pair change in an avirulence gene
- 1 January 1994
- journal article
- Published by Springer Nature in Nature
- Vol. 367 (6461) , 384-386
- https://doi.org/10.1038/367384a0
Abstract
Host genotype specificity in interactions between biotrophic pathogens and plants in most cases complies with the gene-for-gene model; success or failure of infection is determined by absence or presence of complementary genes, avirulence and resistance genes, in the pathogen and host plant, respectively. Resistance, expressed by the induction of a hypersensitive response in the host, is envisaged to be based on recognition of the pathogen, mediated through direct interaction between products of pathogen avirulence genes (the so-called race-specific elicitors) and receptors in the host plant, the putative products of resistance genes. The interaction between the biotrophic fungus Cladosporium fulvum and its only host, tomato (Lycopersicon esculentum), is a well-established model system for studying fungus-plant gene-for-gene relationships. Here we report the isolation of race-specific elicitor AVR4 of C. fulvum and the cloning of its encoding avirulence gene. We present evidence that, in nature, a single base-pair change in this avirulence gene leads to virulence of races previously avirulent on tomato genotypes carrying the complementary Cf4 resistance gene.Keywords
This publication has 12 references indexed in Scilit:
- The AVR9 Race-Specific Elicitor of Cladosporium fulvum Is Processed by Endogenous and Plant ProteasesPlant Physiology, 1993
- Differential accumulation of mRNAs encoding extracellular and intracellular PR proteins in tomato induced by virulent and avirulent races of Cladosporium fulvumPlant Molecular Biology, 1992
- Molecular Characterization of Gene-For-Gene Systems in Plant-Fungus Interactions and the Application of Avirulence Genes in Control of Plant PathogensAnnual Review of Phytopathology, 1992
- Race-specificity of plant resistance to bacterial spot disease determined by repetitive motifs in a bacterial avirulence proteinNature, 1992
- Cloning and Characterization of cDNA of Avirulence Geneavr9of the Fungal PathogenCladosporium fulvum, Causal Agent of Tomato Leaf MoldMolecular Plant-Microbe Interactions®, 1991
- Purification and Serological Characterization of Three Basic 15-Kilodalton Pathogenesis-Related Proteins from TomatoPlant Physiology, 1990
- A Gene fromPseudomonas syringaepv.glycineawith Homology to Avirulence Gene D fromP. s.pv.tomatobut Devoid of the Avirulence PhenotypeMolecular Plant-Microbe Interactions®, 1990
- Molecular basis for evasion of plant host defence in bacterial spot disease of pepperNature, 1988
- Cloned avirulence gene of Pseudomonas syringae pv. glycinea determines race-specific incompatibility on Glycine max (L.) MerrProceedings of the National Academy of Sciences, 1984
- Evidence for the occurrence of race and cultivar-specific elicitors of necrosis in intercellular fluids of compatible interactions of Cladosporium fulvum and tomatoPhysiological Plant Pathology, 1982