Abstract
Review of the history of experimentation in zoology, its failures and successes; factors needing special attention; and fields now open for hopeful work. Successful experimentation requires careful attention to (1) the role of the physical and chemical factors of the environment; (2) the physics and chemistry of the substances of which organisms are composed; (3) the diverse results of different structural arrangements; (4) the role of selective elimination. The fundamental problem for experimental biology is the origin of diversities of structural arrangement.

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