Antibodies against a preselected peptide recognize and neutralize foot and mouth disease virus.
Open Access
- 1 July 1982
- journal article
- research article
- Published by Springer Nature in The EMBO Journal
- Vol. 1 (7) , 869-874
- https://doi.org/10.1002/j.1460-2075.1982.tb01262.x
Abstract
A major antibody combining site on foot and mouth disease virus (FMDV) serotype O1K has been identified in a predicted surface helix of viral protein 1 (VP1) between amino acid residues 144 and 159. A hexadecapeptide covering this sequence elicits high titers of antibodies that specifically recognize and neutralize FMDV. The high quality of the immune response is attributed to a particularly stable conformation of the antigenic amino acid sequence, which is most likely an alpha‐helix.This publication has 29 references indexed in Scilit:
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