Carcinogenicity of Benzo(a)Pyrene and Dusts in the Hamster Lung (Instilled Intratracheally with Titanium Oxide, Aluminum Oxide, Carbon and Ferric Oxide)

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Abstract
The possible carcinogenic or fibrogenic effects of intratracheal instillation of a polycyclic hydrocarbon, benzo(a) pyrene (B(a)P), alone or in combination with several [air polluting] dusts, TiO2, Al2O3, C and Fe2O3, were investigated in hamsters. When administered alone, the dusts induced interstitial cell proliferation, bronchial epithelial alterations and a few granulomatous changes in the pulmonary system, but no tumors. B(a)P alone induced only 2 tracheal papillomas. Combined treatment with B(a)P and the dusts caused a number of tumors, dependent on the dust used. B(a)P plus TiO2 in a small particle size (below 0.5 .mu.) induced papillomas, squamous cell carcinomas and a few adenomas and adenocarcinomas of the larynx, trachea and lungs. These were morphologically similar to neoplasms found after B(a)P and Fe2O3 treatment. B(a)P, combined with C or Al2O3, induced laryngeal and tracheal papillomas. B(a)P and C treated hamsters also showed a few lung adenocarcinomas.

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