CEREBRAL CIRCULATION AND METABOLISM IN PULMONARY EMPHYSEMA AND FIBROSIS WITH OBSERVATIONS ON THE EFFECTS OF MILD EXERCISE 1

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Abstract
Cerebral blood flow, O2 consumption, and vascular resistance were normal in a group of 22 patients with pulmonary emphysema and fibrosis of moderate severity. Mild exercise produced no significant changes in cerebral vascular or metabolic functions, despite a considerable decrease in arterial pH correlation between cerebral blood flow and arterial PCO2 was good, but no correlation was found between cerebral blood flow and arterial PO2 or percent arterial O2 saturation. There was no significant difference in cerebral blood flow as measured by the intermittent sampling technic as compared to the continuous sampling technic in these subjects. These studies reemphasize the important relationship between arterial PCO2 and cerebral blood flow and demonstrate the relative unimportance of the clinical and spirometric severity classification on cerebral blood flow in chronic lung disease.