A Ligand-Accelerated Chiral Lewis Acid Catalyst in Asymmetric Michael Addition of Thiols to α,β-Unsaturated Carbonyls

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Abstract
A novel chiral hafnium catalyst, which was readily prepared from Hf(OTf)4 and chiral ligand 1, has been developed in asymmetric Michael reactions of thiols with 3-(2-alkenoyl)-2-oxazolidinones, affording the corresponding adducts in high yields and enantiomeric excesses. Although chiral Lewis acids are less reactive than their original Lewis acids in many cases, ligand-acceleration has been demonstrated in this asymmetric Michael addition reaction.

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