Nonsuture colonic anastomosis

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Abstract
Methyl-2-cyanoacrylate was used for nonsuture end-to-end anastomosis of the ascending colon in 35 male Sprague-Dawley rats. Seven rats were sacrificed and 8 rats died after the procedure. The mortality rate was 22% in 6 mo. period. Twenty rats are being observed for further studies of the anastomotic site and possible late carcinogenic activity of the monomer. The local histotoxicity of methyl-2-cyanoacrylate, the strong binding capacity, the abundance of scar tissue and the distraction of the mucosa were confirmed in this work. The age of the glue has a significant influence on survival. The use of tissue adhesives as a substitute for standard suture technique or as a reinforcement of an inadequate suture line requires further study. Investigations designed for improving properties of these monomers appear warranted.