Dehydration of 2-Hydroxyimines with Dicyclohexylcarbodiimide: An Access to Cyclic Alkenylimines
- 1 January 1991
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1991 (12) , 916-918
- https://doi.org/10.1055/s-1991-20922
Abstract
2-Methyl-1-aza-1-cycloalkenes 1 react with aldehydes and ketones to yield 2-(2-hydroxyalkyl)-1-aza-1-cycloalkenes 3 under basic conditions. The resulting 2-hydroxyimines 3 are easily dehydrated by dicyclohexylcarbodiimide (DCC) with copper(I) chloride as catalyst in refluxing ether to furnish the corresponding 2-(1-alkenyl)-1-aza-1-cycloalkenes 4.Keywords
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