A Facile Synthesis of Cyanohydrin Trimethylsilyl Ethers by the Addition Reaction of Trimethylsilyl Cyanide with Aldehydes under Basic Condition
- 1 April 1991
- journal article
- research article
- Published by Oxford University Press (OUP) in Chemistry Letters
- Vol. 20 (4) , 537-540
- https://doi.org/10.1246/cl.1991.537
Abstract
In the presence of a catalytic amount of Lewis base such as amine, phosphine, arsine or antimony, trimethylsilyl cyanide (TMS-CN) smoothly reacts with aldehydes to afford the corresponding cyanohydrin trimethylsilyl ethers in excellent yields.Keywords
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