INHIBITION OF THE HIGH-AFFINITY FC RECEPTOR (FC-GAMMA-RI) ON HUMAN-MONOCYTES BY PORPHYRIN PHOTOSENSITIZATION IS HIGHLY SPECIFIC AND MEDIATED BY THE GENERATION OF SUPEROXIDE RADICALS
- 5 July 1989
- journal article
- research article
- Vol. 264 (19) , 11407-11413
Abstract
P72 high affinity receptors (Fe,RI) for the Fc portion of IgG molecules on human peripheral blood monocytes mediate a variety of beneficial functions, but also have deleterious effects in certain clinical situations. In the present study, the photosensitizing porphyrins hematoporphyrin derivative and dihematoporphyrin ether (DHE), which are known to preferentially affect the cell membrane, were found to significantly inhibit binding of mouse IgG2a antibodies to the ligand binding site of Fc.gamma.RI on human peripheral blood monocytes and the U937 human monoclonal antibody which recognizes an epitope distinct from the ligand binding site, indicating that photosensitization induced a structural alteration rather than loss of the receptor molecule from the cell surface. The effect of DHE and light appeared to be highly specific, since binding of monoclonal antibodies to other surface structures was not decreased. DHE plus light-induced modulation of Fc.gamma.RI was found to be mediated by superoxide anions, since addition of a mimic of superoxide dismutase restored both binding of mouse IgG2a to Fc.gamma.RI as well as human monocyte accessory cell function. These studies identify porphyrin photosensitization as a unique mechanism by which to selectively down-regulate Fc7RI-mediated functions.This publication has 18 references indexed in Scilit:
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