The kidney in the hypertensive black
- 1 May 1996
- journal article
- research article
- Published by Taylor & Francis in Ethnicity & Health
- Vol. 1 (2) , 145-151
- https://doi.org/10.1080/13557858.1996.9961781
Abstract
Evidence suggests that the incidence of end‐stage renal disease due to essential hypertension is five to six times more frequent in black than in white patients. The reason for this greater susceptibility is not clear. Several possibilities have been proposed, including socioeconomic factors, compliance with therapy, renal hemodynamic differences and anatomic differences. In this review, we propose that the greater propensity of black hypertensives to develop renal failure as a consequence of hypertension may be due to abnormal hemodynamic adaptation of the renal circulation to a rise in blood pressure caused by high dietary sodium intake. This would make the renal circulation of hypertensive blacks more susceptible to injury.Keywords
This publication has 40 references indexed in Scilit:
- Abnormal renal hemodynamics in black salt-sensitive patients with hypertension.Hypertension, 1991
- Na(+)-H+ antiport activity in skin fibroblasts from blacks and whites.Hypertension, 1990
- Renal Insufficiency in Treated Essential HypertensionNew England Journal of Medicine, 1989
- Role of cellular calcium in salt sensitivity of patients with essential hypertension.Hypertension, 1988
- Sodium responsiveness of central alpha 2-adrenergic receptors in spontaneously hypertensive rats.Hypertension, 1988
- Plasma and urinary catecholamines in salt-sensitive idiopathic hypertension.Hypertension, 1988
- Assessment of human sympathetic nervous system activity from measurements of norepinephrine turnover.Hypertension, 1988
- Racial Differences in the Incidence of Treatment for End-Stage Renal DiseaseNew England Journal of Medicine, 1982
- Hormonal Systems and Renal HemodynamicsAnnual Review of Physiology, 1980
- Plasma and urinary norepinephrine values at extremes of sodium intake in normal man.Hypertension, 1979